The above-mentioned randomized, unblinded study was conducted at the Saint Louis University School of Public Health’s Institute for Biosecurity and was intended to quantify and compare the time required to administer organophosphorous antidotes using traditional equipment versus auto-injectors in two different treatment conditions (either with or without wearing personal protective equipment). Investigators concluded that theuse of ATNAA auto-injectors shortens response time for administering organophosphorous antidote treatment. An ATNAA can be administered in less than half the time it takes to administer a single injection using a needle and syringe or two auto-injectors using a Mark I Kit. Since participants only administered one injection (atropine) with traditional needle and syringe, investigators concluded that the recorded times would have been at least twice as long if two injections (both atropine and pralidoxime chloride) were administered in the same manner.1
Important Safety Information
In the presence of life-threatening poisoning by organophosphorus nerve agents and insecticides, there are no absolute contraindications to the use of AtroPen Auto-Injector. When symptoms of poisoning are less severe AtroPen Auto-Injector should be used with extreme caution in people with arrhythmias, recent myocardial infarction, severe narrow angle glaucoma, pyloric stenosis, prostatic hypertrophy, significant renal insufficiency, or hypersensitivity to any component of the product. Giving additional injections in the absence of actual nerve agent or insecticide poisoning may cause an overdose of atropine which could result in temporary incapacitation and patients with cardiac disease may be at risk for serious adverse events, including death. AtroPen Auto-Injector is Pregnancy Category C and should be administered to a pregnant woman only if clearly needed.
Important Safety Information
Individuals should not rely solely upon agents such as atropine and pralidoxime chloride to provide complete protection from chemical nerve agents and insecticide poisoning. Primary protection against exposure to chemical nerve agents and insecticide poisoning is the wearing of protective garments including masks designed specifically for this use. Evacuation and decontamination procedures should be undertaken as soon as possible. Medical personnel assisting evacuated victims of nerve agent poisoning should avoid contaminating themselves by exposure to the victim’s clothing.
Mild to moderate pain may be experienced at the site of injection. Pralidoxime chloride may cause changes in vision, dizziness, headache, drowsiness, nausea, tachycardia, increased blood pressure, hyperventilation, muscular weakness, and transient elevation of liver enzymes and creatine phosphokinase. When atropine and pralidoxime chloride are used together, the signs of atropinization may occur earlier.